Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1 -/- mouse brain. [electronic resource]
Producer: 20071206Description: 962-75 p. digitalISSN:- 0002-9440
- Animals
- Autophagy
- Brain -- cytology
- Cathepsin B -- metabolism
- Cathepsin D -- metabolism
- Child
- Cholesterol -- metabolism
- Filipin -- metabolism
- Humans
- Intracellular Signaling Peptides and Proteins
- Lysosomes -- metabolism
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Microtubule-Associated Proteins -- metabolism
- Niemann-Pick C1 Protein
- Niemann-Pick Diseases -- metabolism
- Proteins -- genetics
- Purkinje Cells -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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