Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice. [electronic resource]
Producer: 20071106Description: 72-80 p. digitalISSN:- 0014-2999
- ADAM Proteins -- antagonists & inhibitors
- ADAM17 Protein
- Animals
- Capillary Permeability -- drug effects
- Chemokines -- blood
- Cytokines -- blood
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Hydroxamic Acids -- administration & dosage
- Interleukin-10 -- blood
- Intestinal Mucosa -- metabolism
- Intestines -- blood supply
- Lung -- drug effects
- Male
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases -- metabolism
- Mice
- Mice, Inbred C57BL
- Oligopeptides -- administration & dosage
- Reperfusion Injury -- metabolism
- Survival Rate
- Tumor Necrosis Factor-alpha -- blood
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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