IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals. [electronic resource]
Producer: 20070919Description: 939-49 p. digitalISSN:- 0022-1767
- Adoptive Transfer
- Animals
- Apoptosis -- physiology
- Apoptosis Regulatory Proteins -- biosynthesis
- Blotting, Western
- CD4-Positive T-Lymphocytes -- metabolism
- Caspases -- metabolism
- Flow Cytometry
- Gene Expression
- Gene Expression Regulation -- immunology
- Interferon-gamma -- metabolism
- Lymphocyte Activation -- immunology
- Membrane Potential, Mitochondrial
- Mice
- Mice, Knockout
- Mycobacterium Infections -- immunology
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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