Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation. [electronic resource]
Producer: 20070830Description: 197-216 p. digitalISSN:- 0148-0545
- Acylation
- Adenocarcinoma -- drug therapy
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- BALB 3T3 Cells
- Biotransformation
- Body Weight -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Chemical and Drug Induced Liver Injury
- Chromatography, High Pressure Liquid
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Hematocrit
- Humans
- Kidney Diseases -- chemically induced
- Liver -- drug effects
- Liver Diseases -- pathology
- Male
- Methylation
- Mice
- Mice, Transgenic
- Prostatic Intraepithelial Neoplasia -- drug therapy
- Prostatic Neoplasms -- drug therapy
- Spectrometry, Mass, Electrospray Ionization
- Sphingosine -- administration & dosage
- Tissue Distribution
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Extramural
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