XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. [electronic resource]
Producer: 20070906Description: 491-500 p. digitalISSN:- 0893-6692
- Animals
- BRCA2 Protein -- metabolism
- CHO Cells
- Cell Extracts
- Cell Survival -- drug effects
- Chromosomal Instability -- drug effects
- Cricetinae
- Cricetulus
- DNA Damage
- DNA-Binding Proteins -- genetics
- Down-Regulation
- HeLa Cells
- Humans
- Methyl Methanesulfonate -- toxicity
- Micronucleus Tests
- Mutagens -- toxicity
- Mutation -- genetics
- Neoplasms -- pathology
- RNA, Small Interfering -- metabolism
- Sister Chromatid Exchange -- drug effects
- Transfection
- X-ray Repair Cross Complementing Protein 1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
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