Low dose combination of morphine and delta9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors. [electronic resource]
Producer: 20071025Description: 129-37 p. digitalISSN:- 0014-2999
- Analgesics, Non-Narcotic -- administration & dosage
- Analgesics, Opioid -- administration & dosage
- Animals
- Benzoxazines -- pharmacology
- Dose-Response Relationship, Drug
- Dronabinol -- administration & dosage
- Drug Synergism
- Drug Therapy, Combination
- Drug Tolerance
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology
- Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Male
- Morphine -- administration & dosage
- Morpholines -- pharmacology
- Naphthalenes -- pharmacology
- Pain -- metabolism
- Pain Measurement
- Pain Threshold -- drug effects
- Periaqueductal Gray -- drug effects
- Rats
- Rats, Sprague-Dawley
- Receptor, Cannabinoid, CB1 -- agonists
- Receptors, Opioid, mu -- agonists
- Spinal Cord -- drug effects
- Sulfur Radioisotopes
- Time Factors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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