The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. [electronic resource]
Producer: 20071017Description: R1400-9 p. digitalISSN:- 0363-6119
- Animals
- Bile Acids and Salts -- pharmacology
- Biological Evolution
- Cloning, Molecular
- DNA -- genetics
- DNA-Binding Proteins -- drug effects
- Electrophoretic Mobility Shift Assay
- Genes, Reporter -- genetics
- Glutathione Transferase -- metabolism
- Humans
- Lanosterol -- pharmacology
- Ligands
- Luciferases -- genetics
- Models, Molecular
- Phylogeny
- Plasmids -- genetics
- Receptors, Cytoplasmic and Nuclear -- drug effects
- Reverse Transcriptase Polymerase Chain Reaction
- Skates, Fish -- physiology
- Substrate Specificity
- Tissue Distribution
- Transcription Factors -- drug effects
- Tretinoin -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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