Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation. [electronic resource]
Producer: 20070913Description: 632-40 p. digitalISSN:- 0002-9440
- Aminoquinolines -- pharmacokinetics
- Animals
- Bone Marrow Cells -- drug effects
- Cell Shape -- drug effects
- Chemokine CCL2 -- genetics
- Dose-Response Relationship, Drug
- Drug Implants
- Genotype
- Giant Cells, Foreign-Body -- drug effects
- Granulocyte-Macrophage Colony-Stimulating Factor -- pharmacology
- Interleukin-4 -- pharmacology
- Macrophages -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microspheres
- Monomeric GTP-Binding Proteins -- antagonists & inhibitors
- Phagocytosis -- drug effects
- Pseudopodia -- metabolism
- Pyrimidines -- pharmacokinetics
- RNA Interference
- RNA, Small Interfering -- genetics
- rac1 GTP-Binding Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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