Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. [electronic resource]
Producer: 20070809Description: 1393-402 p. digitalISSN:- 1551-4005
- Antibiotics, Antineoplastic -- pharmacology
- Benzoquinones -- pharmacology
- Breast Neoplasms -- pathology
- Carcinoma -- pathology
- Cell Hypoxia
- Cell Line, Tumor -- drug effects
- Cobalt -- pharmacology
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Drug Screening Assays, Antitumor
- Extracellular Matrix Proteins -- metabolism
- Feedback, Physiological
- Female
- Fibronectins -- metabolism
- Focal Adhesions -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Hepatocyte Growth Factor -- antagonists & inhibitors
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- Integrin beta3 -- genetics
- Lactams, Macrocyclic -- pharmacology
- Neoplasm Invasiveness
- Neoplasm Proteins -- biosynthesis
- Neovascularization, Pathologic -- drug therapy
- Proto-Oncogene Proteins c-met -- biosynthesis
- Stress Fibers -- drug effects
- Urinary Bladder Neoplasms -- pathology
- Vascular Endothelial Growth Factor A -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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