Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway. [electronic resource]
Producer: 20070608Description: 489-95 p. digitalISSN:- 1431-6730
- Breast Neoplasms -- genetics
- Cell Line, Tumor
- Down-Regulation
- Early Growth Response Protein 1 -- metabolism
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Expression Regulation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinase Kinases -- metabolism
- Neoplasm Metastasis
- PTEN Phosphohydrolase -- genetics
- Phosphoprotein Phosphatases -- genetics
- Protein Phosphatase 1
- RNA, Messenger
- Tumor Suppressor Proteins -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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