Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT. [electronic resource]
Producer: 20070815Description: 167-74 p. digitalISSN:- 1470-8728
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters -- metabolism
- Adenoviridae
- Animals
- Apolipoprotein A-I -- blood
- Biological Transport
- Cell Line
- Cholesterol -- metabolism
- Chromatography, Liquid
- Enzyme Activation
- Gene Expression Regulation
- Genetic Therapy
- Humans
- Lipids -- blood
- Lipoproteins -- chemistry
- Lipoproteins, HDL -- chemistry
- Liver -- metabolism
- Mice
- Mutant Proteins -- metabolism
- Mutation -- genetics
- Phenotype
- Phosphatidylcholine-Sterol O-Acyltransferase -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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