Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. [electronic resource]
Producer: 20071019Description: 1631-8 p. digitalISSN:- 0006-4971
- Anaphase-Promoting Complex-Cyclosome
- Antigens, CD
- Bone Marrow Cells -- metabolism
- Cadherins -- genetics
- Cell Adhesion -- drug effects
- Cell Line, Tumor
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- Cyclin-Dependent Kinase Inhibitor p27
- G1 Phase -- drug effects
- Humans
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Lymphoma, B-Cell -- enzymology
- Lymphoma, Mantle-Cell -- enzymology
- Models, Biological
- Neoplasm Proteins -- antagonists & inhibitors
- Proteasome Endopeptidase Complex -- genetics
- RNA, Small Interfering -- metabolism
- S-Phase Kinase-Associated Proteins -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Stromal Cells -- metabolism
- Ubiquitin -- genetics
- Ubiquitin-Protein Ligase Complexes -- genetics
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Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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