AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. [electronic resource]
Producer: 20071030Description: 2034-40 p. digitalISSN:- 0006-4971
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Aurora Kinase A
- Aurora Kinase B
- Aurora Kinases
- Case-Control Studies
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Colony-Forming Units Assay
- Daunorubicin -- pharmacology
- Drug Synergism
- Drug Therapy, Combination
- Drug Tolerance
- Enzyme Inhibitors -- pharmacology
- Female
- Flow Cytometry
- Humans
- Immunoblotting
- Leukemia -- drug therapy
- Mice
- Mice, Inbred BALB C
- Organophosphates -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Quinazolines -- pharmacology
- Thymidine -- metabolism
- Transplantation, Heterologous
- Tubulin Modulators -- pharmacology
- Vincristine -- pharmacology
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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