Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. [electronic resource]
Producer: 20070911Description: 3773-80 p. digitalISSN:- 0013-7227
- Animals
- Animals, Genetically Modified
- Blood Pressure -- physiology
- Cardiomegaly -- drug therapy
- Chronic Disease
- Fibrosis
- Magnetic Resonance Imaging
- Male
- Microscopy, Electron, Transmission
- Mineralocorticoid Receptor Antagonists -- pharmacology
- Mitochondria -- metabolism
- Myocardium -- metabolism
- Myocytes, Cardiac -- metabolism
- NADPH Oxidases -- metabolism
- Oxidative Stress -- physiology
- Rats
- Rats, Sprague-Dawley
- Receptors, Mineralocorticoid -- metabolism
- Renin -- genetics
- Renin-Angiotensin System -- drug effects
- Spironolactone -- pharmacology
- Ventricular Dysfunction, Left -- drug therapy
- Ventricular Remodeling -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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