Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. [electronic resource]
Producer: 20070531Description: 2442-50 p. digitalISSN:- 1524-4539
- Active Transport, Cell Nucleus -- drug effects
- Animals
- Aortic Diseases -- drug therapy
- Apolipoproteins E -- deficiency
- Apoptosis
- Atherosclerosis -- drug therapy
- Cells, Cultured -- drug effects
- Chemokine CCL2 -- biosynthesis
- Cholesterol -- blood
- Collagen -- biosynthesis
- Crosses, Genetic
- Diet, Atherogenic
- Drug Evaluation, Preclinical
- Foam Cells -- pathology
- Gene Expression Regulation -- drug effects
- Genotype
- Hydrogen Peroxide -- pharmacology
- Hypercholesterolemia -- blood
- Hypertriglyceridemia -- blood
- Isoquinolines -- pharmacology
- Lipopolysaccharides -- pharmacology
- Macrophages, Peritoneal -- drug effects
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NF-kappa B -- metabolism
- Necrosis
- Oxidative Stress
- Poly Adenosine Diphosphate Ribose -- physiology
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- genetics
- Specific Pathogen-Free Organisms
- Thiophenes -- pharmacology
- Tissue Inhibitor of Metalloproteinase-2 -- metabolism
- Triglycerides -- blood
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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