Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. [electronic resource]
Producer: 20070712Description: 615-22 p. digitalISSN:- 1097-6256
- Amyotrophic Lateral Sclerosis -- genetics
- Animals
- Astrocytes -- chemistry
- Cell Survival -- drug effects
- Cells, Cultured
- Culture Media, Conditioned -- toxicity
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Embryo, Mammalian
- Embryonic Stem Cells -- drug effects
- Enzyme Inhibitors -- pharmacology
- Ganglia, Spinal -- pathology
- Green Fluorescent Proteins -- metabolism
- Humans
- In Situ Nick-End Labeling -- methods
- Mice
- Mice, Transgenic
- Motor Neurons -- cytology
- Mutation
- Nerve Tissue Proteins -- metabolism
- Superoxide Dismutase -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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