Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1. [electronic resource]
Producer: 20070529Description: 369-82 p. digitalISSN:- 1744-6872
- Antineoplastic Agents, Phytogenic -- pharmacology
- Cell Line, Tumor
- Chromatography, Affinity
- Clotrimazole -- pharmacology
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- metabolism
- Electrophoretic Mobility Shift Assay
- Enzyme Inhibitors -- pharmacology
- Growth Inhibitors -- pharmacology
- Histone Acetyltransferases -- metabolism
- Humans
- Immunoprecipitation
- Ligands
- Mutagenesis, Site-Directed
- Mutation -- genetics
- Nuclear Receptor Coactivator 1
- Paclitaxel -- pharmacology
- Plasmids
- Polymorphism, Genetic
- Pregnane X Receptor
- Receptors, Steroid -- genetics
- Rifampin -- pharmacology
- Transcription Factors -- metabolism
- Transcriptional Activation
- Two-Hybrid System Techniques
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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