Delivery of anti-platelet-endothelial cell adhesion molecule single-chain variable fragment-urokinase fusion protein to the cerebral vasculature lyses arterial clots and attenuates postischemic brain edema. [electronic resource]
Producer: 20070730Description: 947-52 p. digitalISSN:- 0022-3565
- Animals
- Blood-Brain Barrier -- drug effects
- Brain -- blood supply
- Brain Chemistry -- drug effects
- Brain Edema -- pathology
- Cerebellum -- drug effects
- Cerebrovascular Circulation -- drug effects
- Drug Delivery Systems -- methods
- Fibrinolysis -- drug effects
- Immunoglobulin Fragments -- genetics
- Injections, Intra-Arterial
- Intracranial Thrombosis -- pathology
- Male
- Mice
- Mice, Inbred C57BL
- Platelet Endothelial Cell Adhesion Molecule-1 -- immunology
- Prodrugs -- administration & dosage
- Recombinant Fusion Proteins -- administration & dosage
- Temporal Lobe -- drug effects
- Thrombolytic Therapy -- methods
- Urokinase-Type Plasminogen Activator -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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