A novel, conformation-specific allosteric inhibitor of the tachykinin NK2 receptor (NK2R) with functionally selective properties. [electronic resource]
Producer: 20070815Description: 2124-34 p. digitalISSN:- 1530-6860
- Allosteric Regulation
- Aminoacetonitrile -- analogs & derivatives
- Animals
- Calcium -- metabolism
- Calcium Signaling -- drug effects
- Cell Line -- drug effects
- Cyclic AMP -- biosynthesis
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Fluorescence Resonance Energy Transfer
- Fluorescent Dyes -- analysis
- Genes, Reporter
- Humans
- Kidney
- Kinetics
- Naphthalenes -- chemical synthesis
- Neurokinin A -- analogs & derivatives
- Protein Binding
- Protein Conformation -- drug effects
- Rats
- Receptors, Neurokinin-2 -- antagonists & inhibitors
- Recombinant Fusion Proteins -- antagonists & inhibitors
- Second Messenger Systems -- drug effects
- Structure-Activity Relationship
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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