The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. [electronic resource]
Producer: 20080214Description: 2520-9 p. digitalISSN:- 0893-133X
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters -- genetics
- Analysis of Variance
- Animals
- Antidepressive Agents, Tricyclic -- pharmacology
- Corticosterone -- blood
- Desipramine -- pharmacology
- Hippocampus -- drug effects
- In Situ Hybridization -- methods
- Male
- Mice
- Mice, Knockout
- RNA, Messenger -- metabolism
- Receptors, Glucocorticoid -- genetics
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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