Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. [electronic resource]
Producer: 20070828Description: 783-97 p. digitalISSN:- 0964-6906
- Acetylcysteine -- pharmacology
- Antioxidants -- pharmacology
- Blotting, Western
- Cell Line, Tumor
- Electron Transport Complex III -- metabolism
- Electron Transport Complex IV -- metabolism
- Humans
- Huntingtin Protein
- Microscopy, Fluorescence
- Mitochondria -- drug effects
- Models, Biological
- Mutation
- Nerve Tissue Proteins -- chemistry
- Nuclear Proteins -- chemistry
- Oxidative Stress
- Peptides -- genetics
- Potassium Cyanide -- pharmacology
- Proteasome Endopeptidase Complex -- metabolism
- Protein Denaturation
- Recombinant Fusion Proteins -- metabolism
- Trinucleotide Repeat Expansion
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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