Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors. [electronic resource]
Producer: 20070514Description: 1514-27 p. digitalISSN:- 0022-2623
- Antineoplastic Agents -- chemical synthesis
- Camptothecin -- pharmacology
- Cell Line, Tumor
- Checkpoint Kinase 1
- Crystallography, X-Ray
- DNA Damage
- Doxorubicin -- pharmacology
- Drug Design
- Drug Screening Assays, Antitumor
- Drug Synergism
- Humans
- Macrocyclic Compounds -- chemical synthesis
- Models, Molecular
- Protein Kinase Inhibitors -- chemical synthesis
- Protein Kinases -- chemistry
- Structure-Activity Relationship
- Urea -- analogs & derivatives
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Publication Type: Journal Article
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