Selective induction of human hepatic cytochromes P450 2B6 and 3A4 by metamizole. [electronic resource]
Producer: 20070926Description: 265-74 p. digitalISSN:- 0009-9236
- Aged
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Aryl Hydrocarbon Hydroxylases -- biosynthesis
- Blotting, Western
- Catalysis
- Cells, Cultured
- Constitutive Androstane Receptor
- Cytochrome P-450 CYP2B6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System -- biosynthesis
- DNA -- biosynthesis
- Dipyrone -- analogs & derivatives
- Dose-Response Relationship, Drug
- Enzyme Induction -- drug effects
- Female
- Genotype
- Hepatocytes -- drug effects
- Humans
- In Vitro Techniques
- Isoenzymes -- metabolism
- Liver -- drug effects
- Male
- Microsomes, Liver -- drug effects
- Middle Aged
- Oxidoreductases, N-Demethylating -- biosynthesis
- Plasmids
- Pregnane X Receptor
- RNA -- biosynthesis
- Receptors, Cytoplasmic and Nuclear -- drug effects
- Receptors, Steroid -- drug effects
- Reverse Transcriptase Polymerase Chain Reaction
- Transcription Factors -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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