Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells. [electronic resource]
Producer: 20070412Description: 2280-9 p. digitalISSN:- 0008-5472
- Amino Acid Sequence
- Cell Line, Tumor
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Core Binding Factor Alpha 2 Subunit -- genetics
- DNA-Binding Proteins -- antagonists & inhibitors
- HL-60 Cells
- HeLa Cells
- Humans
- Jurkat Cells
- Leukemia -- genetics
- Molecular Sequence Data
- Oncogene Proteins, Fusion -- metabolism
- Peptide Fragments -- pharmacology
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- antagonists & inhibitors
- RUNX1 Translocation Partner 1 Protein
- Transcription Factors -- antagonists & inhibitors
- Transcriptional Activation -- drug effects
- Translocation, Genetic
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Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
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