Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects. [electronic resource]
Producer: 20070319Description: 1036-43 p. digitalISSN:- 1524-4628
- Animals
- Blood-Brain Barrier -- drug effects
- Cattle
- Cells, Cultured
- Chiroptera
- Coculture Techniques
- Fibrinolytic Agents -- pharmacokinetics
- Humans
- Low Density Lipoprotein Receptor-Related Protein-1 -- physiology
- Male
- Plasminogen Activators -- pharmacokinetics
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins -- pharmacokinetics
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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