A PK-PD model for predicting the impact of age, CYP2C9, and VKORC1 genotype on individualization of warfarin therapy. [electronic resource]
Producer: 20070425Description: 529-38 p. digitalISSN:- 0009-9236
- Aged
- Aged, 80 and over
- Aging -- metabolism
- Algorithms
- Anticoagulants -- administration & dosage
- Aryl Hydrocarbon Hydroxylases -- genetics
- Cytochrome P-450 CYP2C9
- DNA -- genetics
- Databases, Factual
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases -- genetics
- Models, Statistical
- Pharmacokinetics
- Population
- Stereoisomerism
- Vitamin K Epoxide Reductases
- Warfarin -- administration & dosage
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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