Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation. [electronic resource]
Producer: 20070227Description: 268-72 p. digitalISSN:- 0003-9950
- Antioxidants -- metabolism
- Apoptosis
- Cell Survival
- Cells, Cultured
- DNA, Mitochondrial -- genetics
- Dependovirus -- genetics
- Gene Expression Regulation, Enzymologic -- physiology
- Genetic Therapy
- Genetic Vectors
- Green Fluorescent Proteins -- genetics
- Humans
- In Situ Nick-End Labeling
- Microscopy, Fluorescence
- Mitochondria -- metabolism
- Optic Atrophy, Hereditary, Leber -- enzymology
- Oxidative Stress
- Plasmids
- Reactive Oxygen Species -- metabolism
- Superoxide Dismutase -- genetics
- Superoxides -- toxicity
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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