Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. [electronic resource]
Producer: 20070316Description: 138-46 p. digitalISSN:- 1535-7163
- Animals
- Benzimidazoles -- pharmacology
- Carcinoma, Hepatocellular -- drug therapy
- Caspase 3 -- metabolism
- Caspase 7 -- metabolism
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Humans
- Liver Neoplasms -- drug therapy
- MAP Kinase Kinase Kinase 1 -- antagonists & inhibitors
- Mice
- Mice, SCID
- Phosphorylation -- drug effects
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- metabolism
- Ribosomal Protein S6 Kinases, 90-kDa -- antagonists & inhibitors
- Time Factors
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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