Modeling the cholesteatoma microenvironment: coculture of HaCaT keratinocytes with WS1 fibroblasts induces MMP-2 activation, invasive phenotype, and proteolysis of the extracellular matrix. [electronic resource]
Producer: 20070320Description: 313-8 p. digitalISSN:- 0023-852X
- Cell Communication
- Cell Line
- Cell Movement -- physiology
- Cholesteatoma -- pathology
- Coculture Techniques
- Collagen -- metabolism
- Collagen Type IV -- metabolism
- Drug Combinations
- Enzyme Activation -- physiology
- Enzyme Inhibitors -- pharmacology
- Extracellular Matrix -- metabolism
- Fibroblasts -- physiology
- Fluorescent Dyes
- Humans
- Keratinocytes -- physiology
- Laminin -- metabolism
- Matrix Metalloproteinase 2 -- metabolism
- Microscopy, Confocal
- Phenotype
- Proteoglycans -- metabolism
- Stromal Cells -- physiology
- rac1 GTP-Binding Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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