Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. [electronic resource]
Producer: 20070215Description: 334-44 p. digitalISSN:- 0004-3591
- Activin Receptors, Type I -- genetics
- Animals
- Cell Differentiation -- drug effects
- Cells, Cultured
- Disease Models, Animal
- Female
- Fibroblasts -- drug effects
- Gene Targeting -- methods
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Phosphorylation
- Plasminogen Activator Inhibitor 1 -- metabolism
- Protein C Inhibitor -- metabolism
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- genetics
- Scleroderma, Systemic -- genetics
- Signal Transduction
- Skin -- drug effects
- Smad2 Protein -- metabolism
- Smad3 Protein -- metabolism
- Tamoxifen -- analogs & derivatives
- Transforming Growth Factor beta -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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