Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. [electronic resource]
Producer: 20070202Description: 7731-9 p. digitalISSN:- 0022-2623
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- antagonists & inhibitors
- Benzopyrans -- chemical synthesis
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cisplatin -- pharmacology
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Jurkat Cells
- Lung Neoplasms -- drug therapy
- Nitriles -- chemical synthesis
- Proto-Oncogene Proteins c-bcl-2 -- antagonists & inhibitors
- Structure-Activity Relationship
- Tumor Cells, Cultured -- drug effects
- bcl-X Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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