The autocrine TNFalpha signalling loop in keratinocytes requires atypical PKC species and NF-kappaB activation but is independent of cholesterol-enriched membrane microdomains. [electronic resource]
Producer: 20070423Description: 526-33 p. digitalISSN:- 0006-2952
- Antibodies, Monoclonal -- pharmacology
- Autocrine Communication -- drug effects
- Carbazoles -- pharmacology
- Cell Line
- Cholesterol -- chemistry
- Dose-Response Relationship, Drug
- Humans
- Indoles -- pharmacology
- Infliximab
- Keratinocytes -- cytology
- Membrane Microdomains -- chemistry
- NF-kappa B -- metabolism
- Protein Kinase C -- antagonists & inhibitors
- RNA, Messenger -- genetics
- Receptors, Tumor Necrosis Factor, Type I -- genetics
- Sesquiterpenes -- pharmacology
- Sesquiterpenes, Guaiane
- Signal Transduction -- drug effects
- Tumor Necrosis Factor-alpha -- genetics
- beta-Cyclodextrins -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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