NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. [electronic resource]
Producer: 20070130Description: 1653-62 p. digitalISSN:- 0007-0920
- Adenocarcinoma -- drug therapy
- Animals
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- drug effects
- Carcinoma, Large Cell -- drug therapy
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Carcinoma, Squamous Cell -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27
- Docetaxel
- Down-Regulation
- Drug Combinations
- Glycogen Synthase Kinases -- metabolism
- HIV Protease Inhibitors -- pharmacology
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Lung Neoplasms -- drug therapy
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nelfinavir -- pharmacology
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA, Small Interfering -- pharmacology
- Signal Transduction -- drug effects
- Taxoids -- therapeutic use
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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