Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. [electronic resource]
Producer: 20070312Description: 2829-40 p. digitalISSN:- 0022-1007
- Adaptor Proteins, Signal Transducing -- genetics
- Adoptive Transfer
- Animals
- B-Lymphocytes -- drug effects
- Benzamides
- Cell Differentiation -- drug effects
- Cell Line
- Cell Proliferation -- drug effects
- DNA-Binding Proteins -- genetics
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- Humans
- Imatinib Mesylate
- Intercellular Signaling Peptides and Proteins -- pharmacology
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Leukemia -- genetics
- Mice
- Mice, Inbred BALB C
- Mice, Knockout
- Oxazines -- pharmacology
- Phospholipase C gamma -- genetics
- Phosphorylation -- drug effects
- Piperazines -- pharmacology
- Protein Kinase Inhibitors -- pharmacology
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-myc -- genetics
- Pyridines -- pharmacology
- Pyrimidines -- pharmacology
- Receptors, Antigen, B-Cell -- genetics
- Spleen -- drug effects
- Syk Kinase
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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