Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. [electronic resource]
Producer: 20070423Description: 481-90 p. digitalISSN:- 0006-2952
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cellular Senescence -- drug effects
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Flow Cytometry
- G2 Phase -- drug effects
- Humans
- Immunoblotting
- Mitosis -- drug effects
- Peptide Fragments -- metabolism
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-jun -- metabolism
- Transcription Factor AP-1 -- metabolism
- Tubulin Modulators -- pharmacology
- Vinblastine -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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