Atorvastatin interferes with activation of human CD4(+) T cells via inhibition of small guanosine triphosphatase (GTPase) activity and caspase-independent apoptosis. [electronic resource]
Producer: 20070220Description: 524-32 p. digitalISSN:- 0009-9104
- Apoptosis -- drug effects
- Atorvastatin
- Blotting, Western
- CD4-Positive T-Lymphocytes -- drug effects
- Caspases -- physiology
- Cell Cycle -- drug effects
- Cell Proliferation -- drug effects
- Cytokines -- biosynthesis
- Dose-Response Relationship, Immunologic
- Enzyme Activation -- drug effects
- Heptanoic Acids -- pharmacology
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Interleukin-2 Receptor alpha Subunit -- metabolism
- Lymphocyte Activation -- drug effects
- Monomeric GTP-Binding Proteins -- antagonists & inhibitors
- Pyrroles -- pharmacology
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Publication Type: Journal Article
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