Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors. [electronic resource]
Producer: 20070409Description: 370-5 p. digitalISSN:- 0960-894X
- Animals
- Antineoplastic Agents -- chemical synthesis
- Biological Availability
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Computer Simulation
- Drug Evaluation, Preclinical
- Enzyme Inhibitors -- chemical synthesis
- Histone Deacetylase Inhibitors
- Humans
- Hydroxamic Acids -- chemical synthesis
- Indicators and Reagents
- Mice
- Neoplasm Transplantation
- Neoplasms, Experimental -- drug therapy
- Pyrazoles -- chemical synthesis
- Rats
- Structure-Activity Relationship
- Transplantation, Heterologous
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Publication Type: Journal Article
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