Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. [electronic resource]
Producer: 20061128Description: 11652-64 p. digitalISSN:- 1529-2401
- 4-Aminopyridine -- pharmacology
- Amyloid beta-Peptides -- pharmacology
- Animals
- Brain -- cytology
- Calcium -- metabolism
- Cells, Cultured
- Cyclooxygenase 2 -- metabolism
- Cytokines -- genetics
- Drug Interactions
- Fetus
- Gene Expression -- drug effects
- Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology
- Humans
- Immunohistochemistry -- methods
- Membrane Potentials -- drug effects
- Membrane Proteins -- metabolism
- Microglia -- drug effects
- NF-kappa B -- metabolism
- Neurons -- chemistry
- Patch-Clamp Techniques -- methods
- Peptide Fragments -- pharmacology
- Potassium Channel Blockers -- pharmacology
- Rats
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Shaw Potassium Channels -- genetics
- Signal Transduction -- drug effects
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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