Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. [electronic resource]
Producer: 20061213Description: 6044-51 p. digitalISSN:- 0022-1767
- Animals
- Antibody Formation -- genetics
- Bacterial Proteins -- immunology
- CD4-Positive T-Lymphocytes -- immunology
- Cytokines -- genetics
- Female
- Immunoglobulin G -- immunology
- Mice
- Mice, Mutant Strains
- Pneumococcal Infections -- prevention & control
- Pneumococcal Vaccines -- immunology
- Receptors, Interleukin-1 Type I -- genetics
- Signal Transduction
- Streptococcal Vaccines -- immunology
- Streptococcus pneumoniae -- immunology
- Th2 Cells -- immunology
- Vaccines, Conjugate -- immunology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Retracted Publication
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