Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. [electronic resource]
Producer: 20061222Description: 16454-9 p. digitalISSN:- 0027-8424
- Amino Acid Sequence
- Animals
- Blood Glucose -- metabolism
- Cells, Cultured
- Enzyme Activation
- Fatty Acids -- metabolism
- Gene Expression Regulation
- Hepatocytes -- drug effects
- Humans
- Insulin -- genetics
- Insulin Receptor Substrate Proteins
- Insulin Resistance
- Intracellular Signaling Peptides and Proteins -- chemistry
- Male
- Mice
- Mitogen-Activated Protein Kinase 8 -- deficiency
- Obesity -- metabolism
- Palmitic Acid -- pharmacology
- Phosphoproteins -- chemistry
- Phosphorylation
- Rats
- Substrate Specificity
- Transcription, Genetic -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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