The 13C4 monoclonal antibody that neutralizes Shiga toxin Type 1 (Stx1) recognizes three regions on the Stx1 B subunit and prevents Stx1 from binding to its eukaryotic receptor globotriaosylceramide. [electronic resource]
Producer: 20070116Description: 6992-8 p. digitalISSN:- 0019-9567
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Antibodies, Monoclonal -- immunology
- Crystallography, X-Ray
- Epitope Mapping
- Epitopes -- chemistry
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Protein Conformation
- Protein Subunits -- chemistry
- Receptors, Cell Surface -- metabolism
- Recombinant Fusion Proteins -- chemistry
- Sequence Alignment
- Shiga Toxin 1 -- antagonists & inhibitors
- Shiga Toxin 2 -- antagonists & inhibitors
- Trihexosylceramides -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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