Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. [electronic resource]
Producer: 20061128Description: 9252-9 p. digitalISSN:- 0008-5472
- Animals
- Carcinoma, Squamous Cell -- blood supply
- Cell Line, Tumor
- Down-Regulation -- drug effects
- Female
- Head and Neck Neoplasms -- blood supply
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- biosynthesis
- Lung Neoplasms -- drug therapy
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Nelfinavir -- pharmacology
- Neovascularization, Pathologic -- drug therapy
- Oxygen -- metabolism
- Protease Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Radiation Tolerance -- drug effects
- Random Allocation
- Sp1 Transcription Factor -- metabolism
- Vascular Endothelial Growth Factor A -- biosynthesis
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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