Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression. [electronic resource]
Producer: 20070123Description: 296-307 p. digitalISSN:- 0969-9961
- Animals
- Animals, Newborn
- Antioxidants -- metabolism
- Apoptosis -- drug effects
- Cells, Cultured
- Cerebellar Cortex -- drug effects
- Cytoprotection -- drug effects
- Dose-Response Relationship, Drug
- Extracellular Signal-Regulated MAP Kinases -- drug effects
- Glutathione Peroxidase -- drug effects
- Lipid Peroxidation -- drug effects
- Nerve Degeneration -- drug therapy
- Neurons -- drug effects
- Neuroprotective Agents -- metabolism
- Neurotoxins -- antagonists & inhibitors
- Oxidative Stress -- drug effects
- Oxidopamine -- antagonists & inhibitors
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins c-akt -- drug effects
- Pyruvic Acid -- metabolism
- RNA, Messenger -- drug effects
- Rats
- Signal Transduction -- drug effects
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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