Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity. [electronic resource]
Producer: 20061024Description: 9687-96 p. digitalISSN:- 0022-538X
- Animals
- Capsid Proteins -- genetics
- Codon -- genetics
- Enzyme-Linked Immunosorbent Assay
- Genome, Viral -- genetics
- HeLa Cells
- Humans
- Membrane Proteins -- genetics
- Mice
- Mice, Transgenic
- Phenotype
- Poliomyelitis -- genetics
- Poliovirus -- genetics
- Protein Biosynthesis -- genetics
- Receptors, Virus -- genetics
- Virulence -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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