Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. [electronic resource]
Producer: 20070205Description: 41-8 p. digitalISSN:- 0167-6997
- 2-Methoxyestradiol
- Administration, Oral
- Adult
- Aged
- Antineoplastic Agents, Phytogenic -- administration & dosage
- Antineoplastic Combined Chemotherapy Protocols -- adverse effects
- Area Under Curve
- Breast Neoplasms -- drug therapy
- Docetaxel
- Drug Administration Schedule
- Estradiol -- adverse effects
- Fatigue -- chemically induced
- Female
- Half-Life
- Humans
- Matrix Metalloproteinase 2 -- blood
- Matrix Metalloproteinase 9 -- blood
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Recurrence, Local
- Taxoids -- adverse effects
- Treatment Outcome
- Tubulin Modulators -- administration & dosage
- Urinalysis
- Vascular Cell Adhesion Molecule-1 -- blood
- Vascular Endothelial Growth Factor A -- urine
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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