R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. [electronic resource]
Producer: 20070109Description: 998-1008 p. digitalISSN:- 0022-3565
- Animals
- Antigen-Antibody Complex -- physiology
- Arthritis, Experimental -- pathology
- Arthus Reaction -- physiopathology
- B-Lymphocytes -- drug effects
- Basophils -- drug effects
- Blotting, Western
- Cells, Cultured
- Crystallography
- Double-Blind Method
- Enzyme Inhibitors -- pharmacokinetics
- Fluorescence Polarization Immunoassay
- Humans
- Immunoglobulin G -- biosynthesis
- Inflammation -- drug therapy
- Lipopolysaccharides -- pharmacology
- Macrophages -- drug effects
- Mast Cells -- drug effects
- Mice
- Mice, Inbred BALB C
- Oxazines -- pharmacokinetics
- Platelet Aggregation -- drug effects
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Pyridines -- pharmacokinetics
- Receptors, Fc -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Spleen -- enzymology
- Stimulation, Chemical
- Tetradecanoylphorbol Acetate -- pharmacology
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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