Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. [electronic resource]
Producer: 20060920Description: 246-54 p. digitalISSN:- 1660-2854
- Amyotrophic Lateral Sclerosis -- drug therapy
- Animals
- Astrocytes -- drug effects
- CD40 Antigens -- metabolism
- Cell Count
- Cell Death -- drug effects
- Female
- Fluorescent Antibody Technique, Indirect
- Glial Fibrillary Acidic Protein -- metabolism
- HSP70 Heat-Shock Proteins -- metabolism
- Longevity
- Mice
- Mice, Transgenic
- Motor Neurons -- drug effects
- Neuroglia -- drug effects
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Pentacyclic Triterpenes
- Postural Balance -- drug effects
- Psychomotor Performance
- Superoxide Dismutase -- genetics
- Superoxide Dismutase-1
- Survival Analysis
- Triterpenes -- pharmacology
- Tumor Necrosis Factor-alpha -- metabolism
- Up-Regulation
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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