A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation. [electronic resource]
Producer: 20061206Description: 1-11 p. digitalISSN:- 0006-8993
- Amino Acid Motifs -- drug effects
- Amino Acid Sequence -- physiology
- Amino Acids -- chemistry
- Binding, Competitive -- drug effects
- Cannabinoids -- metabolism
- Cell Line
- Cyclic AMP -- metabolism
- Cyclohexanes -- pharmacology
- Cyclohexanols
- Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacology
- Humans
- Ligands
- Molecular Structure
- Mutation -- genetics
- Phenols -- pharmacology
- Piperidines -- pharmacology
- Pyrazoles -- pharmacology
- Radioligand Assay
- Receptor, Cannabinoid, CB1 -- chemistry
- Rimonabant
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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