4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. [electronic resource]
Producer: 20061107Description: 309-18 p. digitalISSN:- 0041-008X
- Aldehydes -- toxicity
- Animals
- Apoptosis -- drug effects
- Cysteine Proteinase Inhibitors -- toxicity
- Cytochrome P-450 CYP2E1 -- metabolism
- Cytochromes c -- metabolism
- DNA Fragmentation
- Dose-Response Relationship, Drug
- Glutathione -- metabolism
- Glutathione Peroxidase -- antagonists & inhibitors
- Glutathione Reductase -- antagonists & inhibitors
- Glutathione Transferase -- drug effects
- HSP70 Heat-Shock Proteins -- metabolism
- Mitochondria -- drug effects
- Oxidative Stress -- drug effects
- PC12 Cells -- drug effects
- Poly Adenosine Diphosphate Ribose -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Rats
- Reactive Oxygen Species -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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