MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. [electronic resource]
Producer: 20070212Description: e270 p. digitalISSN:- 1549-1676
- Amino Acid Substitution
- Animals
- Bone Marrow Cells -- drug effects
- Bone Marrow Transplantation
- Cell Division -- drug effects
- Cells, Cultured -- drug effects
- Colony-Forming Units Assay
- Cytokines -- pharmacology
- Disease Models, Animal
- Gene Expression Regulation
- Genetic Vectors
- Hematologic Neoplasms -- drug therapy
- Hematopoiesis -- genetics
- Humans
- Janus Kinases -- antagonists & inhibitors
- Megakaryocytes -- drug effects
- Mice
- Mice, Inbred BALB C
- Mutation, Missense
- Myeloid Cells -- drug effects
- Myeloproliferative Disorders -- etiology
- Oncogene Proteins, Fusion -- genetics
- Phosphorylation -- drug effects
- Point Mutation
- Primary Myelofibrosis -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein Processing, Post-Translational -- drug effects
- Receptor, Platelet-Derived Growth Factor alpha -- genetics
- Receptors, Cytokine -- physiology
- Recombinant Fusion Proteins -- adverse effects
- STAT Transcription Factors -- physiology
- Sequence Analysis, DNA
- Signal Transduction -- genetics
- Spleen -- pathology
- Thrombocytosis -- etiology
- Transcription, Genetic
- mRNA Cleavage and Polyadenylation Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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